何宏軒，博士，男，漢族，現為必威精装版app西汉姆联 研究員，博士生導師，動物疫病研究組組長。《Molecular and Biochemistry》，《生物物理和生物化學》，《微生物學報》等雜誌審稿人。中國動物學會和中國畜牧獸醫學會會員。

1993年7月畢業於河南職業技術師範學院，獲學士學位，1998年6月畢業於解放軍農牧大學，獲碩士學位，2002年6月畢業於解放軍軍需大學，獲博士學位，2003年在清華大學生物科學與技術係作博士後研究，2004年在美國康乃爾大學作博士後研究。曾經獲得河南省優秀中青年骨幹教師，河南省教育係統學術技術帶頭人，河南省傑出青年等榮譽。曾在河南科技學院工作，自1996年起先後擔任教研室主任、係副主任、係主任、副院長等職務。1999年7月任講師，2002年6月任副教授，2005年8月任教授。2004年被河北師範大學和河南農業大學聘為碩士生導師，2006年被必威精装版app西汉姆联 聘為博士生導師。

曾主持或參加 “十一五” 國家科技支撐重點項目、國家重點基礎研究發展計劃（973計劃）、國家高技術研究發展計劃（863）、國家自然科學基金、中國博士後基金以及河南省傑出青年基金等20餘項。獲得省部級科研獎7項。在《Emerging infectious diseases》、 《Journal of infectious diseases》、《Reviews in medical virology》 、《Vaccine》、《DNA and Cell Biology》、《Journal of Nanoscience and Nanotechnology》、《生物化學和生物物理進展》等國內外期刊發表學術論文120餘篇。編寫著作9部。

工作經曆

2006年1月－至今 必威精装版app西汉姆联 ，研究員，博士生導師

2005年8月－2005年12月 河南科技學院動物科學學院，教授

2004年10月－2005年11月 美國康乃爾大學獸醫學院，博士後

2003年1月－2004年10月 清華大學生物科學與技術係，博士後

2002年6月－2005年8月 河南科技學院動物科學係，副教授

1999年7月－2002年6月 河南科技學院動物科學係，講師

1993年7月－1999年7月 河南職業技術師範學院畜牧獸醫係，助教

學曆

1999年9月－2002年6月 中國人民解放軍軍需大學畜牧獸醫學院，獲農學博士學位

1996年9月－1998年6月 中國人民解放軍農牧大學畜牧獸醫學院，獲農學碩士學位

1989年9月－1993年6月 河南科技學院畜牧獸醫係，獲農學學士學

　　研究興趣主要集中在了解主要疾病疫源地生態和主要宿主遷徙動態、生境利用及其與家畜和人類活動關係的基礎上，開展病原的檢測和溯源研究，以及病原與宿主的協同進化關係；從人獸共患病病原體和宿主的關係入手，根據生物信息學原理和協同進化理論，運用病原學和分子生物學方法，調查野生動物病原多樣性，揭示自然條件下野生動物源性疫病發生發展規律以及未知病原體/重大疫病對野生動物/家養動物/人類的內在影響機製。

1. 國家重點研發計劃：重大野生動物疫病跨境傳播機製及監測技術研究，課題：重要跨境野生動物病原傳播機製及發生風險，2022-2025
2. 國家自然科學基金重大項目：鼠類對全球變化的響應與適應機製研究，課題：寄生生物對鼠類種群發生的調控作用和製約機製，2020-2025
3. 科技部常規性科技援助項目：青海三江源及埃及阿斯旺地區極端氣候環境下蜱傳疫病分子流行病學及傳播預警新策略關聯研究，2020-2022
4. 國家林業和草原局野生動物疫源疫病監測項目，環京區域野生動物疫源疫病監測防控，2019-2020
5. 中國科學院戰略性先導科技專項（A類）“地球大數據科學工程”項目專題，2018-2022
6. 國家重點研發計劃：珍稀瀕危野生動物重要疫病防控與馴養繁殖技術研究，2018-2020
7. 國家自然科學基金：MicroRNA參與調控微小隱孢子蟲感染缺硒宿主的分子機製研究，2012-2014
8. 國家自然科學基金：TRX-2抗氧化係統在缺硒狀態宿主中抗微小隱孢子蟲感染的作用機製研究，2011-2013
9. 北京市政府項目：現代農業產業技術體係家禽創新團隊疫病控製崗位專家，2010-2020
10. 國家科技支撐計劃，人獸共患病感染動物模型技術研究及我國特有野生動物實驗動物化，課題：重要人獸共患病野生動物野生和室內種群實驗室感染模型的建立及差異性研究，2010-2012
11. 國家重點基礎研究發展計劃，農業鼠害暴發成災規律、預測及可持續控製的基礎研究，2007-2012
12. 國家高技術研究發展計劃，重大動物疫病快速檢測試劑的研發，2007-2010

1. Xing Y, Chen L, Hu B, Li Y, Mai H, Li G, Han S, Wang Y, Huang Y, Tian Y, Zhang W, Gao Y, He H. Therapeutic role of miR-19a/b protection from influenza virus infection in patients with coronary heart disease [J]. Mol Ther Nucleic Acids. 2024, 35(1):102149. doi:10.1016/j.omtn.2024.102149.
2. Huang Y, Zhang P, Han S, Hu B, Zhang Q, He H. Effect of Enteromorpha polysaccharides on gut-lung axis in mice infected with H5N1 influenza virus [J]. Virology. 2024, 593:110031.
3. Zhao Z, Han S, Zhang Q, Wang Y, Yue K, Abbas S, He H. Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3 [J]. Virol J. 2024, 21(1):33.
4. Zhang Q, Zhou Q, Han S, Li Y, Wang Y, He H. The genome of sheep ked (Melophagus ovinus) reveals potential mechanisms underlying reproduction and narrower ecological niches [J]. BMC Genomics, 2023, 24(1): 54.
5. Zhang H, Han S, Wang B, Xing Y, Yuan G, Wang Y, Zhao Z, Li G, Li Q, Pan J, Li W, He H. Genetic Characterization and Pathogenesis of Avian Influenza Virus H3N8 Isolated from Chinese pond heron in China in 2021 [J]. Viruses, 2023, 15(2).
6. Xiao X, Zhang Q, Wu S, Li Y, Zhong Z, Guo Q, Li J, Meng Q, Cheng Z, Duan J, Wang X, He H, Bai J, Lou Y. Detection of Clostridium perfringens Using Novel Methods Based on Recombinase-Aided Amplification Assay-Assisted CRISPR/Cas12a System [J]. Transbound Emerg Dis, 2023, 2023: 6667618.
7. Xiang C, Li Y, Jing S, Han S, He H. Trichomonas gallinae Kills Host Cells Using Trogocytosis [J]. Pathogens, 2023, 12(8).
8. Wu Q, Wang Y, Zhang X, Gu X, He H, Jin X. Pyogranulomatous dermatitis with Enterococcus faecalis in a spotted seal (Phoca larga) [J]. Vet Med Sci, 2023, 9(2): 985-991.
9. Wang Z, Sun X, Chen X, Wang H, He H. The Mass Spectrometry Identification, Antimicrobial Genes Detection, and Proteomics Analysis of Stutzerimonas stutzeri Strain Was Isolated from Industrial Wastewater [J]. Separations, 2023, 10(9): 461.
10. Wang H, Sun C, Chen X, Yan K, He H. Isolation of Pseudomonas oleovorans Carrying Multidrug Resistance Proteins MdtA and MdtB from Wastewater [J]. Molecules, 2023, 28(14).
11. Wang H, Guo J, Chen X, He H. The Metabolomics Changes in Luria-Bertani Broth Medium under Different Sterilization Methods and Their Effects on Bacillus Growth [J]. Metabolites, 2023, 13(8).
12. Wang B, Huang Y, Hu B, Zhang H, Han S, Yang Z, Su Q, He H. Characterization of a reassortant H11N9 subtype avian influenza virus isolated from spot-billed duck in China [J]. Virus Genes, 2023, 59(4): 604-612.
13. Su Q, Chen Y, He H. Molecular evolution of Toll-like receptors in rodents [J]. Integr Zool, 2023.
14. Li G, Zhang T, Hu B, Han S, Xiang C, Yuan G, He H. Infection with Cryptosporidium parvum Affects Secondary Sexual Characteristics of Male Mice by Altering the Pheromone Content in Preputial Gland [J]. Animals (Basel), 2023, 13(4).
15. Li G, Zhang T, Hu B, Han S, Xiang C, Yuan G, He H. Infection of Trichinella spiralis Affects the Reproductive Capacity of ICR/CD-1 Male Mice by Reducing the Urine Pheromone Contents and Sperm Quality [J]. Int J Mol Sci, 2023, 24(6).
16. Li G, Wang Q, Zhang M, Hu B, Han S, Xiang C, Yuan G, He H. Male-Biased Parasitism of Brandt's Voles (Lasiopodomys brandtii) in Inner Mongolia, China [J]. Animals (Basel), 2023, 13(8).
17. Jing S, Zhang Q, Li Y, Chang H, Xiang C, Han S, Yuan G, Fan J, He H. Identification of new drug candidates against Trichomonas gallinae using high-throughput screening [J]. Int J Parasitol Drugs Drug Resist, 2023, 23: 19-27.
18. Huang Y, Zhang P, Han S, He H. Lactoferrin Alleviates Inflammation and Regulates Gut Microbiota Composition in H5N1-Infected Mice [J]. Nutrients, 2023, 15(15).
19. Hu B, Wang J, Li Y, Ge J, Pan J, Li G, He Y, Zhong H, Wang B, Huang Y, Han S, Xing Y, He H. Gut microbiota facilitates adaptation of the plateau zokor (Myospalax baileyi) to the plateau living environment [J]. Front Microbiol, 2023, 14: 1136845.
20. Hu B, Han S, He H. Effect of epidemic diseases on wild animal conservation [J]. Integr Zool, 2023, 18(6): 963-980.
21. Zhang X, Cui K, Wen X, Li L, Yu X, Li B, Lin H, He H, Wang F. The Association between Gut Microbiome Diversity and Composition and Heat Tolerance in Cattle [J]. Microorganisms, 2022, 10(8).
22. Zhang Q, Zhong Z, Xia Z, Meng Q, Shan Y, Guo Q, Cheng Z, Zhang P, He H, Bai J. Molecular Epidemiology and Genetic Diversity of Enterocytozoon bieneusi in Cervids from Milu Park in Beijing, China [J]. Animals (Basel), 2022, 12(12).
23. Zhang P, Zhang Q, Han S, Yuan G, Bai J, He H. Occurrence and Genetic Diversity of the Zoonotic Enteric Protozoans and Enterocytozoon bieneusi in Père David's Deer (Elaphurus davidianus) from Beijing, China [J]. Pathogens, 2022, 11(11).
24. Zhang P, Feng S, Jia T, Han S, Zhang C, He H. Prevalence and genetic diversity of Enterocytozoon bieneusi in nonhuman primates in Northern and Central China [J]. Int J Parasitol Parasites Wildl, 2022, 17: 273-277.
25. Wu Q, Chen L, Zhang Q, Jin X, Tang L, Zhang X, Liu Y, Li J, Pei J, Zhu Q, Jin S, Zhao Q, Shen J, Zhao Z, Jin Y, He H, Gu X, Yang M. Sarcoptic mange is an emerging threat to biodiversity in the Qinling Mountains in China [J]. Transbound Emerg Dis, 2022, 69(6): 3724-3736.
26. Wang H, He H. Detection of Drug-Resistant Kluyvera intermedia from Zoacys dhumnades [J]. Cell Mol Biol (Noisy-le-grand), 2022, 68(9): 97-101.
27. Su Q, Chen Y, Wang B, Zhang Q, He H. Genetic characterizations of Toll-like receptors in the brown rat and their associations with pathogen infections [J]. Integr Zool, 2022, 17(5): 879-889.
28. Ren Z, Okyere S K, Zhang M, Zhang X, He H, Hu Y. Glycine Nano-Selenium Enhances Immunoglobulin and Cytokine Production in Mice Immunized with H9N2 Avian Influenza Virus Vaccine [J]. Int J Mol Sci, 2022, 23(14).
29. Hu B, Wang J, Zhang S, Wang B, Xing Y, Han S, He H. Novel genotypes of Cryptosporidium and Enterocytozoon bieneusi detected in plateau zokors (Myospalax baileyi) from the Tibetan Plateau [J]. Int J Parasitol Parasites Wildl, 2022, 19: 263-268.
30. Zhang Q X, Wang Y, Li Y, Han S Y, Wang B, Yuan G H, Zhang P Y, Yang Z W, Wang S L, Chen J Y, Zhong H S, Han X Q, He H X. Vector-Borne Pathogens with Veterinary and Public Health Significance in Melophagus ovinus (Sheep Ked) from the Qinghai-Tibet Plateau [J]. Pathogens, 2021, 10(2).
31. Zhang Q, Meng M, Huang C, Feng S, Liu J, Tang Y, Fan Y, Yuan G, Han S, Luo J, Zhao B, He H. Identification and genetic characterization of Contracaecum sp. (Nematoda: Anisakidae) from China [J]. Integr Zool, 2021, 16(6): 929-938.
32. Zhang Q, Liu J, Han S, Wang B, Su Q, Yuan G, He H. Genetic and evolutionary characterization of avian paramyxovirus type 4 in China [J]. Infect Genet Evol, 2021, 91: 104777.
33. Wang Y, Zhang Q, Han S, Li Y, Wang B, Yuan G, Zhang P, Yang Z, Zhang H, Sun Y, Chen J, Han X, He H. Ehrlichia chaffeensis and Four Anaplasma Species With Veterinary and Public Health Significance Identified in Tibetan Sheep (Ovis aries) and Yaks (Bos grunniens) in Qinghai, China [J]. Front Vet Sci, 2021, 8: 727166.
34. Wang Y, Wang B, Zhang Q, Li Y, Yang Z, Han S, Yuan G, Wang S, He H. The Common Occurrence of Theileria ovis in Tibetan Sheep and the First Report of Theileria sinensis in Yaks from Southern Qinghai, China [J]. Acta Parasitol, 2021, 66(4): 1177-1185.
35. Wang B, Su Q, Luo J, Li M, Wu Q, Chang H, Du J, Huang C, Ma J, Han S, Yuan G, He Y, Guo M, Zhang Q, He H. Differences in Highly Pathogenic H5N6 Avian Influenza Viral Pathogenicity and Inflammatory Response in Chickens and Ducks [J]. Front Microbiol, 2021, 12: 593202.
36. He Y C, Li J X, Sun Y L, Kang M, He H X, Guo Y H, Ma P, Wei Y P, Li R S, Chen W K, Chen Z H, Li J, Qi T S, Yang J F, Zhang Q X, Wang Y, Cai J S, Zhao Q B, Hu G W, Chen J Y, Li Y. Spotted Fever Group Rickettsia Infecting Ticks (Acari: Ixodidae), Yak (Bos grunniens), and Tibetan Sheep (Ovis aries) in the Qinghai-Tibetan Plateau Area, China [J]. Front Vet Sci, 2021, 8: 779387.
37. Feng S, Chang H, Wang Y, Luo F, Wu Q, Han S, He H. Lethal infection caused by Tetratrichomonas gallinarum in black swans (Cygnus atratus) [J]. BMC Vet Res, 2021, 17(1): 191.
38. Zhang Q, Luo D, Xie Z, He H, Duan Z. The Oncogenic Role of miR-BART19-3p in Epstein-Barr Virus-Associated Diseases [J]. Biomed Res Int, 2020, 2020: 5217039.
39. Wang H, Guo J, Zheng L, Liu S, Wang Z, He H. Detection of new antibiotic resistance gene profile in Escherichia coli associated with avian leukosis virus infection from broiler chickens [J]. BIOCELL, 2020, 44(2).
40. Su Q, Chen Y, Wang B, Huang C, Han S, Yuan G, Zhang Q, He H. Epidemiology and genetic diversity of zoonotic pathogens in urban rats (Rattus spp.) from a subtropical city, Guangzhou, southern China [J]. Zoonoses Public Health, 2020, 67(5): 534-545.
41. Feng S, Jia T, Huang J, Fan Y, Chang H, Han S, Luo J, He H. Identification of Enterocytozoon bieneusi and Cryptosporidium spp. in farmed wild boars (Sus scrofa) in Beijing, China [J]. Infect Genet Evol, 2020, 80: 104231.
42. Feng S, Chang H, Wang Y, Huang C, Han S, He H. Molecular Characterization of Cryptosporidium spp. in Brandt's Vole in China [J]. Front Vet Sci, 2020, 7: 300.
43. Chang H, Feng S, Wang Y, Li F, Su Q, Wang B, Du J, He H. Isolation and Pathogenic Characterization of Pigeon Paramyxovirus Type 1 via Different Inoculation Routes in Pigeons [J]. Front Vet Sci, 2020, 7: 569901.
44. Zhang Q, Liu K, Wang C, Luo J, Lu J, He H. Molecular Characterization of Entamoeba spp. in Wild Taihangshan Macaques (Macaca mulatta tcheliensis) in China [J]. Acta Parasitol, 2019, 64(2): 228-231.
45. Zhang Q, Han S, Liu K, Luo J, Lu J, He H. Occurrence of Selected Zoonotic Fecal Pathogens and First Molecular Identification of Hafnia paralvei in Wild Taihangshan Macaques (Macaca mulatta tcheliensis) in China [J]. Biomed Res Int, 2019, 2019: 2494913.
46. Wang H, Chen L, Luo J, He H. NP and NS1 proteins of H5N1 virus significantly upregulated IFITM1, IFITM2, and IFITM3 in A549 cells [J]. Afr Health Sci, 2019, 19(1): 1402-1410.
47. Su Q, Chen Y, Li M, Ma J, Wang B, Luo J, He H. Genetic Characterization and Molecular Evolution of Urban Seoul Virus in Southern China [J]. Viruses, 2019, 11(12).
48. Meng W, Yang Q, Vrancken B, Chen Z, Liu D, Chen L, Zhao X, François S, Ma T, Gao R, Ru W, Li Y, He H, Zhang G, Tian H, Lu J. New evidence for the east-west spread of the highly pathogenic avian influenza H5N1 virus between Central Asian and east Asian-Australasian flyways in China [J]. Emerg Microbes Infect, 2019, 8(1): 823-826.
49. Li M, Feng S, Lv S, Luo J, Guo J, Sun J, He H. Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, China [J]. Emerg Microbes Infect, 2019, 8(1): 377-380.
50. Feng S Y, Chang H, Luo J, Huang J J, He H X. First report of Enterocytozoon bieneusi and Cryptosporidium spp. in peafowl (Pavo cristatus) in China [J]. Int J Parasitol Parasites Wildl, 2019, 9: 1-6.
51. Du J, Luo J, Huang J, Wang C, Li M, Wang B, Wang B, Chang H, Ji J, Sen K, He H. Emergence of Genetic Diversity and Multi-Drug Resistant Campylobacter jejuni From Wild Birds in Beijing, China [J]. Front Microbiol, 2019, 10: 2433.