胡寶洋，博士，必威精装版app西汉姆联 研究員，中國科學院大學醫學院常務副院長。入選中國科學院相關人才計劃、教育部高層次人才獎勵計劃特聘教授、中青年科技創新領軍人才、百千萬人才工程國家級人選等。中國細胞生物學學會理事、幹細胞分會副會長。

2004年獲複旦大學上海醫學院博士學位，2005年赴美國威斯康星大學（University of Wisconsin-Madison）從事博士後研究，2011年1月回國任職。主要從事幹細胞與再生醫學研究。擔任幹細胞及相關領域國家重要規劃編製專家，積極參與生物技術領域發展規劃、重大項目設計、新興交叉學科設立、重大科技基礎設施建設等。

承擔科技部、國家自然科學基金委、中國科學院、北京市等多項科技任務。領導團隊在人腦發育及退行病變研究等方麵取得係列重要成果。首次揭示 lncRNA起源人特異新基因產物對大腦皮層擴增和折疊的作用及機製；首次闡明 TMEM119 在維持小膠質細胞穩態及調控阿爾茨海默病進程中的作用機製；首次把人iPS細胞分化為神經細胞；開發基於幹細胞的再生醫學產品，率先針對帕金森病等適應證開展臨床研究。在Nature、Science等期刊發表高水平論文80餘篇，獲多項國內外專利。獲中華醫學科技一等獎（8/15）、中國科學院傑出科技成就獎（主要完成者）、第七屆僑屆傑出貢獻獎一等獎、中國細胞生物學會幹細胞分會創新獎、轉化獎等。

領導中國科學院大學醫學學科建設，係統規劃再生醫學、精準醫學、智慧醫學等新興交叉學科和專業領域。突出科學精神、學術視野、創新思維和實戰能力，構建醫藥領域創新領軍人才培養體係；領導建設新型研發機構北京幹細胞與再生醫學研究院，探索以高價值知識產權為載體，聯接並促進更原創突破和更高效成果轉化的模式。

作為主要成員發起成立亞洲幹細胞與再生醫學聯盟（AASCRM）；牽頭組織幹細胞領域高端國際會議PSConf，並任PSConf 2025主席。

當選北京市第十六屆人大代表、政協北京市懷柔區第六屆委員會常委、懷柔區科協副主席等。

揭示人腦發育與疾病機理

結合人多能幹細胞神經定向分化和類器官係統，揭示人腦發育與疾病機製。

研發神經退行疾病創新療法

創新理念、範式和技術，開發衰老和神經退行病變的‘生物技術+’解決方案。

開發治療重大疾病的細胞新藥

以多能幹細胞定向分化和體細胞直接轉分化為基礎，研製新型幹細胞藥物。

享受國務院特殊津貼專家（2020）；中青年科技創新領軍人才（2020）；教育部高層次人才獎勵計劃特聘教授（2019）；百千萬人才工程國家級人選（2019）

2023 北京市自然科學二等獎（證書號 2023-Z04-2-03-R04）4/10

2020 中國科學院傑出科技成就獎

2021 全國科技係統抗擊新冠肺炎疫情先進個人，科技部

2020 抗擊新冠肺炎疫情先進個人，中國農工民主黨中央委員會

2019 幹細胞成果創新獎，中國細胞生物學會幹細胞生物學分會

2018 幹細胞成果轉化獎，中國細胞生物學會幹細胞生物學分會

2018 第七屆中國僑屆傑出貢獻獎一等獎，中國僑聯

2018 中華醫學科技獎一等獎 (證書號201801069P1508) 8/15

2017 中華醫學科技獎三等獎 (證書號201703185P0804) 4/8

國家重大科學研究計劃項目，國家重點研發計劃項目，國家自然科學基金項目，中國科學院重點部署項目，中國科學院戰略性先導科技專項，等。

1. Jing Liu^#, Zhimeng Wang^#, Wenwen Liang, Zhenhao Zhang, Yusen Deng, Xiaowei Chen, Zongren Hou, Yuanzhi Xie, Qi Wang, Yuan Li, Chaobo Bai, Da Li, Fan Mo, Huinan Wang, Dongmei Wang, Junliang Yuan^*, Yukai Wang^*, Zhaoqian Teng^*, Baoyang Hu^*. Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer's disease. Immunity, 2025. 58(7):1830-1846.e7.
2. Yuanzi Xie^#, Jing Liu^#, Zongren Hou^#, Huan Wang^#, Kailun Liu, Xiaowei Chen, Zhen Fan, Da Li, Can Li, Yuhualei Pan, Yushang Zhao, Yanbing Zhu^*, Baoyang Hu^*. CD4-Derived Double-Negative T Cells Ameliorate Alzheimer's Disease-Like Phenotypes in the 5xFAD Mouse Model. CNS Neuroscience & Therapeutics, 2025. 31(1):e70187.
3. Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi, Chuanyue Wang, Yukai Wang^*, Baoyang Hu^*. Human Midbrain Organoids Enriched With Dopaminergic Neurons for Long- Term Functional Evaluation. Cell Proliferation, 2025. 58(7):e70005.
4. Kailun Liu, Xiaowei Chen, Zhen Fan, Fei Ren^*, Jing Liu^*, Baoyang Hu^*. From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research. Chinese Medical Journal, 2025. 138(7):792-807.
5. Yanyu Li^#, Liwei Zhou^#, Fengcui Qian^#, Qiaoli Fang^#, Zhengmin Yu, Ting Cui, Fujuan Dong, Fuhong Cai, Tingting Yu, Lidong Li, Qiuyu Wang, Yanbing Zhu^*, Huifang Tang^*, Baoyang Hu^*, Chunquan L^i*. scImmOmics: a manually curated resource of single-cell multi-omics immune data. Nucleic Acids Research, 2024. 53(D1):D1162-D1172.
6. Lin Feng^#, Da Li^#, Yao Tian^#, Chengshun Zhao, Qi Gu, Wei Li, Jie Hao, Baoyang Hu^*, Yukai Wang^*. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo. Neural Regeneration Research, 2024. 19 (2): 458-464.
7. Liangjiang Huang^#, Song Zhang^#, Jun Wu^#, Baojie Guo^#, Tingting Gao, Sayed Zulfiqar Ali Shah, Bo Huang, Yajie Li, Bo Zhu, Jiaqi Fan, Liu Wang, Yani Xiao, Wenjing Liu, Yao Tian, Zhengyu Fang, Yingying Lv, Lingfeng Xie, Sheng Yao, Gaotan Ke, Xiaolin Huang, Ying Huang, Yujuan Li, Yi Jia, Zhongwen Li, Guihai Feng, Yan Huo, Wei Li, Qi Zhou, Jie Hao^*, Baoyang Hu^*, Hong Chen^*. Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial. Signal Transduction and Targeted Therapy, 2023. 8(1):417.
8. Ni A An^#, Jie Zhang^#, Fan Mo^#, Xuke Luan^#, Lu Tian, Qing Sunny Shen, Xiangshang Li, Chunqiong Li, Fanqi Zhou, Boya Zhang, Mingjun Ji, Jianhuan Qi, Weizhen Zhou, Wanqiu Ding, Jiayu Chen, Jia Yu, Li Zhang, Shaokun Shu, Baoyang Hu^*, Chuanyun Li^*. De novo genes with an lncRNA origin encode unique human brain developmental functionality. Nature Ecology & Evolution, 2023. 7(2): 264-278.
9. Jianhuan Qi^#, Fan Mo^#, Ni A An^#, Tingwei Mi, Jiaxin Wang, Juntian Qi, Xiangshang Li, Boya Zhang, Longkuo Xia, Yingfei Lu, Gaoying Sun, Xinyue Wang, Chuanyun Li^*, Baoyang Hu^*. A Human-Specific De Novo Gene Promotes Cortical Expansion and Folding. Advanced Science, 2023. 13: e2204140.
10. Juan Yu^#, Nianye Yu^#, Yao Tian^#, Yifan Fang#, Bin An, Guihai Feng, Jun Wu, Liu Wang, Jie Hao, Liqiang Wang, Qi Zhou, Wei Li^*, Yukai Wang^*, Baoyang Hu^*. Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction. Cell & Bioscience, 2023. 13(1):201.
11. Wenliang Zhu^#, Mengqi Li^#, Jun Zou^#, Da Zhang, Minghui Fang, Yun Sun, Can Li, Mingming Tang, Yukai Wang, Qi Zhou, Tongbiao Zhao^*, Wei Li^*, Zheng Hu^*, Baoyang Hu^*. Induction of local immunosuppression in allogeneic cell transplantation by cell-type-specific expression of PD-L1 and CTLA4Ig. Stem Cell Reports, 2023. 18(12):2344-2355.
12. Gaoying Sun^#, Mingming Tang^#, Xinyue Wang^#, Da Li, Wenwen Liu, Jianhuan Qi, Haibo Wang^*, Baoyang Hu^*. Generation of human otic neuronal organoids using pluripotent stem cells. Cell Proliferation, 2023. 56(5):e13434.
13. Jing Liu^#, Zongren Hou^#, Jun Wu^#, Kailun Liu, Da Li, Tingting Gao, Wenjing Liu, Bin An, Yun Sun, Fan Mo, Liu Wang, Yukai Wang^*, Jie Hao^*, Baoyang Hu^*, Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. Cell Proliferation, 2021. 54(8): p. e13085.
14. Han Sun, Jing Liu, Fengting Lv, Libing Liu, Qi Gu, Baoyang Hu^*, Shu Wang^*, Selective reaction of conjugated polymers with basic proteins for broad-spectrum antivirulence therapy. NPG Asia Materials, 2021. 13(21).
15. Jun Wu^#, Dingyun Song^#, Zhongwen Li^#, Baojie Guo^#, Yani Xiao, Wenjing Liu, Lingmin Liang, Chunjing Feng, Tingting Gao, Yanxia Chen, Ying Li, Zai Wang, Jianyan Wen, Shengnan Yang, Peipei Liu, Lei Wang, Yukai Wang, Liang Peng, Glyn Nigel Stacey, Zheng Hu, Guihai Feng, Wei Li, Yan Huo, Ronghua Jin, Ng Shyh-Chang, Qi Zhou, Liu Wang, Baoyang Hu^*, Huaping Dai^*, Jie Hao^*. Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. Cell Research, 2020. 30 (9): p. 794-809.
16. Wenliang Zhu^#, Boya Zhang^#, Mengqi Li^#, Fan Mo, Tingwei Mi, Yihui Wu, Zhaoqian Teng, Qi Zhou^*, Wei Li^*, Baoyang Hu^*. Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome. Nature Communications, 2019. 10(1): p. 928.
17. Weiqi Zhang^#, Haifeng Wan^#, Guihai Feng^#, Jing Qu#, Jiaqiang Wang, Yaobin Jing, Ruotong Ren, Zunpeng Liu, Linlin Zhang, Zhiguo Chen, Shuyan Wang, Yong Zhao, Zhaoxia Wang, Yun Yuan, Qi Zhou, Wei Li^*, Guanghui Liu^*, Baoyang Hu^*. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature, 2018. 560(7720): p. 661-665.
18. Zhikun Li^#, Leyun Wang^#, Libin Wang^#, Guihai Feng^#, Xuewei Yuan^#, Chao Liu, Kai Xu, Yuhuan Li, Haifeng Wan, Ying Zhang, Yufei Li, Xin Li, Wei Li*, Qi Zhou^*, Baoyang Hu^*. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell, 2018. 23(5): p. 665-676.
19. Xuepeng Wang^#, Tianda Li^#, Tongtong Cui^#, Dawei Yu^#, Chao Liu^#, Liyuan Jiang, Guihai Feng, Lei Wang, Rui Fu, Xinxin Zhang, Jie Hao, Yukai Wang, Liu Wang, Qi Zhou^*, Wei Li^*, Baoyang Hu^*. Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis. Cell Research, 2018. 28(1): p. 126-129.
20. Menghua Wu, Da Zhang, Chunying Bi, Tingwei Mi, Wenliang Zhu, Longkuo Xia, Zhaoqian Teng, Baoyang Hu^*, Yihui Wu^*. A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs. Stem Cell Reports, 2018. 11(3): p. 635-650.
21. Yukai Wang, Wanwan Zhu, Menghua Wu, Yihui Wu, Zhengxin Liu, Lingmin Liang, Chao Sheng, Jie Hao, Liu Wang, Wei Li, Qi Zhou^*, Baoyang Hu^*. Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease. Stem Cell Reports, 2018. 11(1):171-182.
22. Boya Zhang^#, Yangzhige He^#, Yanpeng Xu^#, Fan Mo, Tingwei Mi, Qing Sunny Shen, Chunfeng Li, Yali Li, Jing Liu, Yihui Wu, Guilai Chen, Wenliang Zhu, Chengfeng Qin^*, Baoyang Hu^*, Guomin Zhou^*. Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids. Cell Death and Disease, 2018. 9(7):719.
23. Yuan Jiang^#, Long Yan^#, Longkuo Xia, Xiaoyin Lu, Wenliang Zhu, Dewen Ding, Mingxia Du, Da Zhang, Hongmei Wang^*, Baoyang Hu^*. Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. The Journal of Biological Chemistry, 2018. 293(50): p. 19317-19329.
24. Zhikun Li^#, Haifeng Wan^#, Guihai Feng^#, Leyun Wang^#, Zhengquan He, Yukai Wang, Xiujie Wang, Wei Li^*, Qi Zhou^*, Baoyang Hu^*. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Research, 2016. 26(1):135-138.
25. Lixiang Ma, Baoyang Hu, Yan Liu, Scott Christopher Vermilyea, Huisheng Liu, Lu Gao, Yan Sun, Xiaoqing Zhang, Suchun Zhang^*. Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell, 2012. 10(4):455-464.
26. Yuan Jiang, Meijiang Zhang, Baoyang Hu^*. Specification of functional neurons and glia from human pluripotent stem cells. Protein Cell, 2012. 3(11):818-825.
27. Baoyang Hu, Jason P Weick, Junying Yu, Lixiang Ma, Xiaoqing Zhang, James A Thomson, Suchun Zhang^*. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proceedings of National Academy of Sciences of The United States of America, 2010. 107(9):4335-4340.
28. Baoyang Hu, Suchun Zhang^*, Differentiation of spinal motor neurons from pluripotent human stem cells. Nature Protocols, 2009. 4(9):1295-1304.
29. Baoyang Hu, Zhongwei Du, Suchun Zhang^*. Differentiation of human oligodendrocytes from pluripotent stem cells. Nature Protocols, 2009. 4(11): 1614-1622.
30. Baoyang Hu, Zhongwei Du, Xuejun Li, Melvin Ayala, Suchun Zhang^*. Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development, 2009. 136(9):1443-1452.

Notes:  # These authors contributed equally; * Correspondence.

專利：

1. 周琪; 李偉; 胡寶洋; 郝捷; 王磊; 王柳。具有特定HLA配型的人胚幹細胞。發明專利，ZL202010949011.X
2. 周琪; 李偉; 胡寶洋; 何正泉; 王柳; 郝捷。一種將非神經元細胞轉化為神經元細胞的方法。發明專利，ZL202010322427.9
3. 周琪; 胡寶洋; 郝捷; 李偉; 吳駿; 王柳; 郭保傑; 李仲文; 高婷婷; 陳燕霞; 王紅梅。一種多能幹細胞、藥物組合物及其製備方法與用途。發明專利，ZL202010998258.0
4. 周琪; 李偉; 郝捷; 王昱凱; 胡寶洋; 馮琳; 梁靈敏; 王柳。一種神經細胞組合和其應用。發明專利，ZL202211191890.X
5. 周琪; 李偉; 胡寶洋; 郝捷; 王磊; 王柳。一種簡單的視網膜色素上皮細胞的配製方法。發明專利，ZL202111136904.3
6. 周琪; 胡寶洋; 李偉; 王昱凱; 王鑫閣; 郝捷; 馮桂海; 田瑤; 馮琳; 王柳。一種通過血樣檢測判斷動物體內存在移植物的方法。發明專利，ZL202211324662.5
7. 周琪; 李偉; 胡寶洋; 郝捷; 王磊; 王柳; 王昱凱。一種視網膜色素上皮細胞的擴增培養基及培養方法。發明專利，ZL202211205216.2
8. 周琪; 李偉; 胡寶洋; 郝捷; 王磊; 王柳。將胚胎幹細胞誘導為視網膜色素上皮細胞的培養基及應用。發明專利，ZL202011220950.7
9. 王崧; 胡寶洋。一種TALE重複序列載體的構建方法。發明專利，ZL201610266044.8
10. 蔣遠; 杜明霞; 胡寶洋。一種提高體細胞重編程效率的培養基及方法。發明專利，ZL201510528329.X
11. Zhang SC, Hu BY, Du ZW. Method of Generating Myelinating Oligodendrocytes from Embryonic Stem Cells, US patent, 2012: US 8227247 B2
12. Zhang SC, Hu BY, Du ZW. Myelinating Oligodendrocyte Precursor Populations, US patent, 2014: US 8658424 B2

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