焦建偉，博士，必威精装版app西汉姆联 研究員，博士生導師，神經幹細胞增殖與分化研究組組長，中國科學院大學崗位教授。國家傑出青年科學基金項目獲得者，國家重點研發計劃首席科學家，科技部中青年科技創新領軍人才。

　　2002年在北京大學生命科學學院獲得博士學位，2002年到2007年在美國哈佛醫學院從事博士後研究，2008年被提升為Instructor。2009年到2011年在中科院神經所任研究員。2011年8月加入中科院動物所任研究員。實驗室主要從事腦發育及疾病機理研究，神經幹細胞增殖與分化調控研究，遺傳和表觀遺傳對神經發育調控機製研究，以及神經細胞轉分化研究。 研究成果發表於國際期刊Cell, Cell Stem Cell, Dev Cell, PNAS, Adv Sci, Sci Adv, Mol Psychiatry, Cell Res, Trends Cell Biol等70多篇。是神經學會理事，生理學會理事，細胞學會幹細胞生物學分會委員，神經學會神經發育與再生分會委員等。目前承擔國家基金委傑出青年基金，重點項目，科技部重點研發項目，中科院先導項目等。

　　神經係統發育是一個受時間和空間精細調控的過程，任何一個環節出現問題，都可能引起嚴重的腦發育異常及相關疾病。圍繞腦發育的發生發展開展係統性研究，以遺傳與表觀遺傳調控為切入點，多角度、多層次闡釋腦發育及神經幹細胞增殖分化的調控機製。主要研究方向: 1.探討神經幹細胞增殖機製，發現新的調控神經幹細胞自我更新和增殖的關鍵因子，探索腦大小及腦溝回形成的關鍵分子及機製，研究腦發育異常的調控因素及機製；2.研究神經元及神經膠質細胞分化的調控機理，解析內源因子和外源信號通路如何協同調控神經幹細胞-神經元及神經膠質細胞轉化過程，研究關鍵基因與信號通路間動態變化的協同調控所發生的細胞命運轉換、細胞形態以及細胞遷移之間的關係，揭示神經細胞分化和遷移的調控機製；3.研究神經元轉分化，為移植細胞治療腦疾病治療提供可能的細胞來源。以上發現將有助於闡明腦發育機製及疾病致病機理，為相關疾病的診治提供潛在靶點，為轉化研究奠定理論基礎。

　　國家傑出青年科學基金，國家自然科學基金重點項目，國家重點研發計劃幹細胞重點專項，國家重大基礎研究計劃項目，中科院戰略先導科技專項等。

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2. He T, Zhang M, Qin J, Wang Y, Li S, Du C, Jiao J*, Ji F*. Endothelial PD-1 Regulates Vascular Homeostasis and Oligodendrogenesis during Brain Development. Adv Sci (Weinh). 2025. doi: 10.1002/advs.202417410
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5. Wang Y, Wang W, Su L, Ji F, Zhang M, Xie Y, Zhang T, Jiao J*. BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development. Dev Cell. 2024 59:108-124.
6. Li Y, Li Z, Wang C, Yang M, He Z, Wang F, Zhang Y, Li R, Gong Y, Wang B, Fan B, Wang C, Chen L, Li H, Shi P, Wang N, Wei Z, Wang YL, Jin L*, Du P*, Dong J*, Jiao J*. Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain. Cell. 2023 186:5892-5909.
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8. Su L, Zhang M, Ji F, Zhao J, Wang Y, Wang W, Zhang S, Ma H, Wang Y, Jiao J*. Microglia homeostasis mediated by epigenetic ARID1A regulates neural progenitor cells response and leads to autism-like behaviors. Mol Psychiatry. 2022 (accepted)
9. Li Y, Li Z, Yang M, Wang F, Zhang Y, Li R, Li Q, Gong Y, Wang B, Fan B, Wang C, Chen L, Li H, Ong J, Teng Z, Jin L*, Wang YL*, Du P*, Jiao J*. Decoding the temporal and regional specification of microglia in the developing human brain. Cell Stem Cell. 2022 29:620-634.
10. Zhao J, Feng C, Wang W, Su L, Jiao J*. Human SERPINA3 induces neocortical folding and improves cognitive ability in mice. Cell Discov. 2022 8:124
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12. Wang W, Su L, Wang Y, Li C, Ji F, Jiao J*. Endothelial Cells Mediated by UCP2 Control the Neurogenic-to-Astrogenic Neural Stem Cells Fate Switch During Brain Development. Adv Sci. 2022 9:2105208.
13. Wang W, Su L, Ji F, Zhang D, Wang Y, Zhao J, Jiao RD, Zhang M, Huang E, Jiang H, Zhang J, Jiao J*. The human FOXM1 homolog promotes basal progenitor cell proliferation and cortical folding in mouse. EMBO Rep. 2022 23:e53602.
14. Ji F*, Wang W, Feng C, Gao F, Jiao J*. Brain-specific Wt1 Deletion Leads to Depressive-like Behaviors in Mice via the Recruitment of Tet2 to Modulate Epo Expression. Mol Psychiatry. 2021 26:4221-4233.
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18. Feng C, Zhao J, Ji F, Su L, Chen Y, Jiao J*. TCF20 dysfunction leads to cortical neurogenesis defects and autistic-like behaviors in mice. EMBO Rep. 2020 21:e49239.
19. Liang Q, Su L, Zhang D, Jiao J^*. CD93 negatively regulates astrogenesis in response to MMRN2 through the transcriptional repressor ZFP503 in the developing brain. Proc Natl Acad Sci USA. 2020 117:9413-9422.
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23. Xia W, Su L, Jiao J^*. Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability during cold stress. J Cell Biol. 2018 217:3464-3479.
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38. Xia W, Liu Y, Jiao J^*. GRM7 regulates embryonic neurogenesis via CREB and YAP. Stem Cell Reports. 2015 4:795-810.
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