李偉，研究員，博士生導師，器官再生與智造重點實驗室（中國科學院）主任。2006年獲武漢大學理學學士學位，2012年獲中國科學院大學理學博士學位，2013年加入必威精装版app西汉姆联 工作。作為通訊/共同通訊作者在Cell、Science、Nature等期刊發表論文60餘篇，獲授權發明專利20餘項；研究成果多次入選“中國科學十大進展”和“中國生命科學十大進展”；基於工作進展轉化的多個基因與細胞治療藥物進入臨床試驗階段。獲得國家傑出青年科學基金、優秀青年科學基金、日本實驗動物學會“國際獎”、中國科學院“青年科學家獎”、中國科學院傑出科技成就獎（突出貢獻者）、中國科學院朱李月華優秀教師獎等資助和獎勵。

結合基因工程、細胞工程和合成生物學等手段發展哺乳動物工程生物學這一新的使能平台，探索哺乳動物器官再生修複的機理與路徑，開發重大疾病的生物治療新方法。

　　主持國家重點研發計劃項目、中國科學院穩定支持基礎研究領域青年團隊計劃項目等。

(^#：第一作者；*：通訊作者)

1. Chen Y^#, Luo S^#, Hu Y^#, Mao B^#, Wang X^#, Lu Z^#, Shan Q, Zhang J, Wang S, Feng G, Wang C, Liang C, Tang N, Niu R, Wang J, Han J, Yang N, Wang H, Zhou Q*, Li W*. All-RNA-mediated targeted gene integration in mammalian cells with rationally engineered R2 retrotransposons. Cell 2024 Aug 22;187(17):4674-4689.e18. doi: 10.1016/j.cell.2024.06.020. Epub 2024 Jul 8.
2. Cui T^#, Cai B^#, Tian Y, Liu X, Liang C, Gao Q, Li B, Ding Y, Li R, Zhou Q, Li W*, Teng F*. Therapeutic In Vivo Gene Editing Achieved by a Hypercompact CRISPR-Cas12f1 System Delivered with All-in-One Adeno-Associated Virus. Advanced Science (Weinh) 2024 May;11(19):e2308095. doi: 10.1002/advs.202308095. Epub 2024 Feb 26. (Cover story)
3. Wang C^#, Fang S^#, Chen Y^#, Tang N, Jiao G, Hu Y, Li J, Shan Q, Wang X, Feng G, Zhou Q*, Li W*. High-efficiency targeted transgene integration via primed micro-homologues. Cell Discovery 2023 Jul 4;9(1):69. doi: 10.1038/s41421-023-00552-0.
4. Wang LB^#, Li ZK^#, Wang LY^#, Xu K^#, Ji TT^#, Mao YH, Ma SN, Liu T, Tu CF, Zhao Q, Fan XN, Liu C, Wang LY, Shu YJ, Yang N, Zhou Q*, Li W*. A sustainable mouse karyotype created by programmed chromosome fusion. Science 2022 Aug 26;377(6609):967-975. doi: 10.1126/science.abm1964. Epub 2022 Aug 25.
5. Chen Y^#, Hu Y^#, Wang X^#, Luo S, Yang N, Chen Y, Li Z, Zhou Q*, Li W*. Synergistic engineering of CRISPR-Cas nucleases enables robust mammalian genome editing. Innovation (Camb). 2022 May 26;3(4):100264. doi: 10.1016/j.xinn.2022.100264.
6. He ZQ^#, Li YH^#, Feng GH^#, Yuan XW^#, Lu ZB^#, Dai M, Hu YP, Zhang Y, Zhou Q*, Li W*. Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons. Advanced Science (Weinh). 2022 May;9(13):e2104682. doi: 10.1002/advs.202104682.
7. Hu Y^#, Chen Y^#, Xu J^#, Wang X, Luo S, Mao B, Zhou Q*, Li W*. Metagenomic discovery of novel CRISPR-Cas13 systems. Cell Discovery 2022 Oct 11;8(1):107. doi: 10.1038/s41421-022-00464-5.
8. Guo L, Sun X, Wang X, Liang C, Jiang H, Gao Q, Dai M, Qu B, Fang S, Mao Y, Chen Y, Feng G, Gu Q, Wang RR*, Zhou Q*, Li W*. SARS-CoV-2 detection with CRISPR diagnostics. Cell Discovery 2020 May 19;6:34. doi: 10.1038/s41421-020-0174-y.
9. Wang LY^#, Li ZK^#, Wang LB^#, Liu C^#, Sun XH^#, Feng GH^#, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL*, Li W*, Zhou Q*. Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. Cell Stem Cell 2020 Aug 6;27(2):315-325.e5. doi: 10.1016/j.stem.2020.05.014.
10. Qu B^#, Wu S^#, Jiao G^#, Zou X^#, Li Z^#, Guo L^#, Sun X, Huang C, Sun Z, Zhang Y, Li H, Zhou Q, Sui R*, Li W*. Treating Bietti crystalline dystrophy in a high-fat diet-exacerbated murine model using gene therapy. Gene Therapy 2020 Aug; 27(7-8):370-382.doi: 10.1038/s41434-020-0159-3.
11. Mao J^#, Xu K^#, Han J^#, Feng G, Zhang Y*, Li W*. Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon. Protein & Cell 2020 Jun;11(6):452-457. doi: 10.1007/s13238-020-00702-0.
12. Teng F^#, Guo L^#, Cui T, Wang XG, Xu K, Gao Q, Zhou Q*, Li W*. CDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity. Genome Biology 2019b Jul 1;20(1):132. doi: 10.1186/s13059-019-1742-z.
13. Teng F^#, Li J^#, Cui T^#, Xu K, Guo L, Gao Q, Feng G, Chen C, Han D, Zhou Q*, Li W*. Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds. Genome Biology 2019a Feb 5;20(1):15. doi: 10.1186/s13059-019-1620-8.
14. Li Y^#, Wang L^#, Zhang L^#, He Z^#, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y*, Zhou Q*, Li W*. Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. Journal Of Cell Biology 2019 May 6;218(5):1553-1563. doi: 10.1083/jcb.201808088.
15. Wang J^#, Wang L^#, Feng G^#, Wang Y^#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W*, Zhou Q*. Asymmetric expression of LincGET biases cell fate in two-cell mouse embryos. Cell 2018 Dec 13;175(7):1887-1901.e18. doi: 10.1016/j.cell.2018.11.039.
16. Teng F^#, Cui T^#, Feng G, Guo L, Xu K, Gao Q, Li T, Li J, Zhou Q, Li W*. Repurposing CRISPR-Cas12b for mammalian genome engineering. Cell Discovery 2018 Nov 27;4:63. doi: 10.1038/s41421-018-0069-3.
17. Zhang W^#, Wan H^#, Feng G^#, Qu J^#, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu G*, Hu B*. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature 2018 Aug;560(7720):661-665. doi: 10.1038/s41586-018-0437-z.
18. Li ZK^#, Wang LY^#, Wang LB^#, Feng GH^#, Yuan XW^#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W*, Zhou Q*, Hu BY*. Generation of bimaternal and bipaternal mice from hypomethylated haploid escs with imprinting region deletions. Cell Stem Cell 2018 Nov 1;23(5):665-676.e4. doi: 10.1016/j.stem.2018.09.004.
19. Xu K^#, Yang Y^#, Feng GH^#, Sun BF^#, Chen JQ^#, Li YF, Chen YS, Zhang XX, Wang CX, Jiang LY, Liu C, Zhang ZY, Wang XJ, Zhou Q*, Yang YG*, Li W*. Mettl3-mediated m⁶A regulates spermatogonial differentiation and meiosis initiation. Cell Research 2017 Sep;27(9):1100-1114. doi: 10.1038/cr.2017.100. (Cover story)
20. Li X^#, Cui XL^#, Wang JQ^#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*. Generation and application of mouse-rat allodiploid embryonic stem cells. Cell 2016 Jan 14;164(1-2):279-292. doi: 10.1016/j.cell.2015.11.035.
21. Wan HF^#, Feng CJ^#, Teng F^#, Yang SH^#, Hu BY, Niu YY, Xiang P, Fang WZ, Ji WZ, Li W*, Zhao XY*, Zhou Q*. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Research 2015 Feb;25(2):258-261. doi: 10.1038/cr.2014.158.
22. Li W^#, Li X^#, Li TD^#, Jiang MG^#, Wan HF, Luo GZ, Feng CJ, Cui XL, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha JH, Xiao YM, Wang L, Liu ZH, Wang XJ, Zhao XY, Zhou Q*. Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell 2014 Mar 6;14(3):404-414. doi: 10.1016/j.stem.2013.11.016.
23. Li W^#, Teng F^#, Li T, Zhou Q*. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nature Biotechnology 2013 Aug;31(8):684-686. doi: 10.1038/nbt.2652.
24. Li W^#, Shuai L^#, Wan H^#, Dong M^#, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY*, Zhou Q*. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 2012 Oct 18;490(7420):407-411. doi: 10.1038/nature11435.
25. Zhao XY^#, Li W^#, Lv Z^#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F*, Zhou Q*. iPS cells produce viable mice through tetraploid complementation. Nature 2009 Sep 3;461(7260):86-90. doi: 10.1038/nature08267.

　　獨立之精神，自由之思想。