呂赫喆， 必威精装版app西汉姆联 膜生物學國家重點實驗室研究員。2011年於北京師範大學獲得細胞生物學博士學位，後於美國賓夕法尼亞大學、加拿大Lunenfeld-Tanenbaum研究所從事腫瘤異質性方麵的博士後研究。2020年7月加入必威精装版app西汉姆联 成立細胞異質性與命運決定研究組。研究內容圍繞膜信號在引發重大疾病的罕見細胞中的作用，利用單細胞分析技術和DNA條形碼技術研究細胞命運軌跡，並應用高通量藥物篩選技術篩選抗腫瘤先導化合物。取得了係列研究成果，分別發表於Nature、Cell Reports、Development Cell等雜誌。目前任International journal of biological sciences、Journal of Genetics and Genomics等雜誌特邀審稿人。
　　現有博士研究生2名、碩士研究生2名、聯合培養研究生1名。

　　實驗室主要聚焦細胞異質性在疾病發生、發展中的作用，結合細胞生物學和生物信息學等手段，研究（1）探尋罕見耐藥腫瘤細胞並設計靶點藥物；（2）研究細胞發生致癌基因突變後的命運軌跡；（3）研究T細胞異質性，篩選刺激T細胞向腫瘤侵襲的小分子藥物。

1. Hezhe Lu, Shujing Liu, Gao Zhang, Bin Wu, Yueyao Zhu, Dennie T. Frederick, Yi Hu, Wenqun Zhong, Sergio Randell, Norah Sadek, Wei Zhang, Gang Chen, Chaoran Cheng, Jingwen Zeng, Lawrence Wu, Jie Zhang, Xiaoming Liu, Wei Xu, Clemens Krepler, Katrin Sproesser, Min Xiao, Benchun Miao, Jianglan Liu, Claire D. Song, Jephrey Y. Liu, Giorgos C. Karakousis, Lynn M. Schuchter, Yiling Lu, Gordon Mills, Yusheng Cong, Jonathan Chernoff, Jun Guo, Genevieve M. Boland, Ryan J. Sullivan, Zhi Wei, Jeffrey Field, Ravi K. Amaravadi, Keith T. Flaherty, Meenhard Herlyn*, Xiaowei Xu*, Wei Guo*  PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature (2017) 550(7674):133-136.   
2. Hezhe Lu, Shujing Liu, Gao Zhang, Lawrence N. Kwong, Yueyao Zhu, John P. Miller, Yi Hu, Wenqun Zhong, Jingwen Zeng, Lawrence Wu, Clemens Krepler, Katrin Sproesser, Min Xiao, Wei Xu, Giorgos C. Karakousis, Lynn M. Schuchter, Jeffery Field, Paul J. Zhang, Meenhard Herlyn, Xiaowei Xu*, Wei Guo* Oncogenica BRAF-induced invadopodia formation and melanoma invasion. Cell Reports. (2016) 15(9): 2012–2024.  
3. Hezhe Lu, Jianglan Liu, Shujing Liu, Jingwen Zeng, Deqiang Ding, Russ P. Carstens, Yusheng Cong, Xiaowei Xu and Wei Guo* Exo70 isoform switching upon Epithelial-Mesenchymal transition mediates cancer cell invasion. Developmental Cell. (2013) 27(5): 560-573.  
4. Hezhe Lu, Ellen Fan, Suozhu Sun, Xiaoxiao Ma, Xiaoyan Zhang, David M.K. Han, and Yu-Sheng Cong* Cyr61 Is Up-Regulated in Prostate Cancer and Associated With the p53 Gene Status. J Cell Biochem. (2009) 106 (4): 738-744. 
5. Shujing Liu, Suresh M Kumar, Hezhe Lu, Aihua Liu, Ruifeng Yang, Anitha Pushparajan, Wei Guo and Xiaowei Xu* MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1–Snail1 pathway in melanoma. Journal of Pathology. (2012) 226: 61–72.
6. Suresh M Kumar, Shujing Liu, Hezhe Lu, Hongtao Zhang, Paul J. Zhang, Phyllis A. Gimotty, Matthew Guerra, Wei Guo and Xiaowei Xu* Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation. (2012) Oncogene. 31(47):4898-91.1
7. Claude C Warzecha, Peng Jiang, Karine Amirikian, Kimberly A Dittmar, Hezhe Lu, Shihao Shen, Wei Guo, Yi Xing and Russ P Carstens* An ESRP-regulated splicing programme is abrogated during the epithelial–mesenchymal transition. EMBO J. (2010) 29 (19):3286-3300.