劉壘，必威精装版app西汉姆联 器官再生與智造全國重點實驗室研究員。主要從事線粒體自噬機製的研究，鑒定了一個新的哺乳動物線粒體自噬受體蛋白FUNDC1，並進一步闡明了FUNDC1介導線粒體自噬的分子機製。發表SCI論文30餘篇，以第一作者或通訊作者在Nature Cell Biology，EMBO Journal，EMBO Reports，Cell Research, Autophagy等雜誌發表多篇論文，其中Nature Cell Biology論文他引800餘次，相關的研究工作受到了國際同行的廣泛認可和高度評價。目前主要從事線粒體及其他細胞器質量控製的分子機製、生理和病理意義的研究。

　　線粒體及其他細胞器穩態調控與疾病。

　　盧嘉錫青年人才獎 2014

• 　　國家自然科學基金重大研究計劃培育項目，主持
• 　　國家自然科學基金麵上項目，主持
• 　　國家重點研發計劃重點專項子課題，負責人

1. Wu H*, Wei H, Zhang D, Sehgal SA, Zhang D, Wang X, Qin Y, Liu L*, Chen Q*. Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy. Redox Biol. 2020 Sep; 36:101661. (Co-corresponding author)
2. Liu L, Liao X, Wu H, Li Y, Zhu Y, Chen Q*. Mitophagy and its contribution to metabolic and aging associated disorders. Antioxidants & Redox Signaling (invited review) 2020 Apr 20;32(12):906-927.  
3. Wu H, Wang Y, Li W, Chen H, Du L, Liu D, Wang X, Xu T, Liu L*, Chen Q*. Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome. Autophagy 2019 Mar 22:1-17 (Co-corresponding author)  
4. Li Y, Xue Y, Xu X, Wang G, Liu Y, Wu H, Li W, Wang Y, Chen Z, Zhang W, Zhu Y, Ji W, Xu T, Liu L*, Chen Q* A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. EMBO Journal 2019 Feb 1 38(3).
5. Liu D, Wu H, Wang C, Li Y, Tian H, Siraj S, Sehgal SA, Wang X, Wang J, Shang Y, Jiang Z, Liu L*, Chen Q*. STING directly activates autophagy to tune the innate immune response. Cell Death and Differentiation 2019 Sep;26(9):1735-1749.(Co-corresponding author)  
6. Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y, Han Z, Chen L, Gao R, Liu L*, Chen Q*. Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy 2016 2(4)：689-702 (Co-corresponding author; Highlighted by both EMBO Journal and by Faculty 1000 )
7. Wu H, Xue D, Chen G, Han Z, Huang L, Zhu C, Wang X, Jin H, Wang J, Zhu Y, Liu L*, Chen Q*.The Bcl-xL and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy 2014 10:1712-25 (Co-corresponding author)
8. Liu L, Sakakibara K, ChenQ*, Okamoto K*. Receptor-mediated mitophagy in yeast and mammalian systems. Cell Research, 2014 24(7):787-95.
9. Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, Huang L, Xue P, Li B, Wang X, Jin H, Wang J, Yang F, Liu P, Zhu Y, Sui S, Chen Q*. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nature Cell Biology, 2012 14(2)177-85 (Landmark paper for mitophagy, Highlighted by Nature China and by Faculty 1000)