郭靖濤，必威精装版app西汉姆联 研究員，器官再生與智造全國重點實驗室副主任。

2013年本科畢業於北京大學，後赴美國猶他大學攻讀博士，畢業後在猶他大學醫學院繼續深造，進行博士後研究。2020年7月受聘於猶他大學醫學院，任準聘助理教授，組建獨立課題組，並獲多個NIH R01基金資助。2021年12月加入必威精装版app西汉姆联 幹細胞與生殖生物學國家重點實驗室，任研究組組長。2022年入選國家海外高層次人才計劃；獲中國科學院戰略先導項目、國家重點研發計劃、國家自然科學基金麵上項目等多個國家級項目資助。以第一作者或通訊作者（含共同）在Cell、 Cell Stem Cell、 Nature Cell Biology、 Nature Aging、 Nature Communications、 Developmental Cell、 Cell Research等期刊上發表研究成果,並受邀在中國、美國、德國、瑞典等多個研究所和高校分享研究成果。長期擔任Cell Stem Cell、 Nature Aging、 Nature Communications、 Cell Reports Medicine等期刊獨立審稿人。

1.人類精原幹細胞的發育與分化調控

發現一類人類特有的精原幹細胞類型，提出人類精原幹細胞雙向可逆的發育模型，為精原幹細胞的體外培養及分化提供了候選的靶標分子。

2. 男性生殖細胞和睾丸微環境生理狀態的關鍵事件

係統研究從早期胚胎到青春期和成年期的睾丸發育過程，提出睾丸內生殖細胞和體細胞的發育模型，闡明精原幹細胞的完整建立過程，為優化青少年腫瘤生育力保存技術提供新思路。

3. 男性不育和生殖腫瘤的病理機製

研究包括隱睾症在內的男性不育疾病，揭示隱睾患者的精子發生障礙主要源於精原受損，睾丸內生精微環境的功能異常，特別是肥大細胞增多和激活脫顆粒等，為未來臨床的精確診斷和針對性治療策略提供了依據。

4. 基於人工智能的計算生物學工具推動男性不育診療

基於全麵的多中心大樣本量臨床數據，引入機器學習模型來預測非梗阻性無精子症(NOA)男性在接受顯微睾丸精子提取（micro-TESE）的預後。開發在線工具SpermFinder（https://huggingface.co/spaces/SpermFinder/TESE），預測取精成功率(SRR)，為術前評估和患者知情臨床決策提供見解。

　（#共同第一作者, *通訊作者）

1. Xi Y^#, Zhang B^#, Zhang Y^#, Zhao L, Liu D, Mao J, Tang W, Zhang H, Lin H, Wang X, Ren P, Tang Y, Yang Y, Hong K*, Guo J*, Zhang Z*, Jiang H*. Machine learning-based personalized prediction of sperm retrieval in patients with non-obstructive azoospermia prior to microdissection testicular sperm extraction: A multi-center cohort study. Andrology. 2025 Sep 8.
2. Ba Omar H^#, Stevens J^#, Haavisto A, Cui Y, Harteveld F, Yang Y, Bjarnason R, Romerius P, Sundin M, Nyström UN, Langenskiöld C, Vogt H, Frisk P, Vepsäläinen K, Petersen C, Cui L, Guo J, Jahnukainen K*, Stukenborg JB*. Early transcriptional states of spermatogonia and marker expressions in the prepubertal human testis following chemotherapy-induced depletion. Hum Reprod. 2025 Aug 1;40(8):1467-1475.
3. Yuan Y^#, Wang X^#, Yan X^#, He N^#, Lu X^#, Yang J^#, Xie X^#, Yuan H, Chen N, Liu Y, Ren H, Zhang R, Cui L, Ren P, Lin S, Cheng S, Yang X, Guo Y, Li R, Yan T, Guo J*, Xiao Z*, Wei Y*, Yu L*.3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation. Cell Stem Cell. 2025 Jun 5.
4. Cui L^#, Nie X^#, Guo YX^#, Ren P, Guo YF, Wang X, Li R, Hotaling JM, Cairns BR*, Guo J*. Single-cell transcriptomic atlas of human testis across the reproductive lifespan. Nature Aging. 2025 Mar 3. (On Line)
5. Jiang Q, Cui L, Nie X, Cai H, Zhang W, Lu X, Guo Y, Hotaling JM, Cairns BR, Wang X*, Guo J*. A single-cell transcriptome atlas characterizes the immune landscape of human testes during aging. Aging Cell. 2025 Mar 6;e70032.
6. Cui L^#, Lin S^#, Yang X^#, Xie X^#, Wang X^#, He N^#, Yang J, Zhang X, Lu X, Yan X, Guo Y, Zhang B, Li R, Miao H, Ji M, Zhang R, Yu L*, Xiao Z*, Wei Y*, Guo J*. Spatial transcriptomic characterization of a Carnegie stage 7 human embryo. Nat Cell Biol. 2025 Feb;27(2):360-369.
7. Wang X^#, Cheng L^#, Lu X^#, Jin H^#, Cui L, Guo Y, Guo J*, Xu EY*. Cross-species comparative single-cell transcriptomics highlights the molecular evolution and genetic basis of male infertility. Cell Rep. 2024 Dec 30;44(1):115118.
8. Wang X^#, Wang Y^#, Wang Y^#, Guo Y^#, Zong R, Hu S, Yue J, Yao J, Han C*, Guo J*, Zhao J*. Single-cell transcriptomic and cross species comparison analyses reveal distinct molecular changes of porcine testes during puberty. Commun Biol. 2024 Nov 9;7(1):1478.
9. Wang X^#, Liu Q^#, Zhuang Z^#, Cheng J, Zhang W, Jiang Q, Guo Y, Li R, Lu X, Cui L, Weng J, Tang Y, Yue J, Gao S, Hong K, Qiao J, Jiang H*, Guo J*, Zhang Z*. Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling. Cell Rep Med. 2024 Sep 17;5(9):101709.
10. Cui Y, Harteveld F, Ba Omar HAM, Yang Y, Bjarnason R, Romerius P, Sundin M, Norén Nyström U, Langenskiöld C, Vogt H, Henningsohn L, Frisk P, Vepsäläinen K, Petersen C, Mitchell RT, Guo J, Alves-Lopes JP, Jahnukainen K, Stukenborg JB. Prior exposure to alkylating agents negatively impacts testicular organoid formation in cells obtained from childhood cancer patients. Hum Reprod Open. 2024 Aug 13;2024(3):hoae049.
11. Xiao Z^#, Cui L^#, Yuan Y^#, He N^#, Xie X, Lin S, Yang X, Zhang X, Shi P, Wei Z, Li Y, Wang H, Wang X*, Wei Y*, Guo J*, Yu L*. 3D reconstruction of a gastrulating human embryo. Cell. 2024 May 23;187(11):2855-2874.e19.
12. Lu X^#, Luo Y^#, Nie X^#, Zhang B, Wang X, Li R, Liu G, Zhou Q, Liu Z, Fan L, Hotaling JM, Zhang Z*, Bo H*, Guo J*. Single-cell multi-omics analysis of human testicular germ cell tumor reveals its molecular features and microenvironment. Nat Commun. 2023 Dec 20;14(1):8462.
13. Wamaitha SE^#, Nie X^#, Pandolfi EC, Wang X, Yang Y, Stukenborg JB, Cairns BR, Guo J*, Clark AT*. Single-cell analysis of the developing human ovary defines distinct insights into ovarian somatic and germline progenitors. Dev Cell. 2023 Oct 23;58(20):2097-2111.e3.
14. Matilionyte G, Forsyth G, Guo J, Rimmer MP, Hermann BP, Anderson RA, Mitchell RT. Granulocyte-colony stimulating factor does not prevent in vitro cisplatin-induced germ cell reduction in immature human and mouse testis.  BMC Cancer. 2023 Mar 16 ;23(1):251.
15. Nie X, Munyoki SK, Sukhwani M, Schmid N, Missel A, Emery BR, DonorConnect, Stukenborg JB, Mayerhofer A, Orwig KE, Aston KI, Hotaling JM, Cairns BR*, Guo J*. Single-Cell Analysis of Human Testis Aging and Correlation with Elevated Body Mass Index. Dev Cell. 2022 May 9;57(9):1160-1176.e5.
16. Wang X, Cairns BR*, Guo J*. When spermatogenesis meets human aging and elevated body mass. Life Med. 2022 Jul 9;1(3):267-269.
17. Mahyari E^#, Guo J^#*, Lima AC, Lewinsohn DP, Stendahl AM, Vigh-Conrad KA, Nie X, Nagirnaja L, Rockweiler NB, Carrell DT, Hotaling JM, Aston KI, Conrad DF*. Comparative single-cell analysis of biopsies clarifies pathogenic mechanisms in Klinefelter syndrome. Am J Hum Genet. 2021 Oct 7;108(10):1924-1945.
18. Patel DP, Punjani N, Guo J, Alukal JP, Li PS, Hotaling JM*. The impact of SARS-CoV-2 and COVID-19 on male reproduction and men's health. Fertil Steril. 2021 Apr;115(4):813-823.
19. Guo J*, Sosa E, Chitiashvili T, Nie X, Rojas EJ, Oliver E; DonorConnect; Plath K, Hotaling JM, Stukenborg JB, Clark AT*, Cairns BR*. Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment. Cell Stem Cell. 2021 Apr 1;28(4):764-778.e4.
20. Tharmalingam MD, Matilionyte G, Wallace WHB, Stukenborg JB, Jahnukainen K, Oliver E, Goriely A, Lane S, Guo J, Cairns B, Jorgensen A, Allen CM, Lopes F, Anderson RA, Spears N, Mitchell RT. Cisplatin and carboplatin result in similar gonadotoxicity in immature human testis with implications for fertility preservation in childhood cancer. BMC Med. 2020 Dec 4 ;18(1):374.
21. Murphy PJ^#*, Guo J^#, Jenkins TG, James ER, Hoidal JR, Huecksteadt T, Broberg DS, Hotaling JM, Alonso DF, Carrell DT, Cairns BR*, Aston KI*. NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure. PLoS Genet. 2020 Jun 10;16(6):e1008756.
22. Guo J, Nie X, Giebler M, Mlcochova H, Wang Y, Grow EJ; DonorConnect; Kim R, Tharmalingam M, Matilionyte G, Lindskog C, Carrell DT, Mitchell RT, Goriely A, Hotaling JM, Cairns BR*. The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty. Cell Stem Cell. 2020 Feb 6;26(2):262-276.e4.
23. Guo J*, Cairns BR. Isolation and Enrichment of Spermatogonial Stem Cells From Human Testis Tissues. Curr Protoc Stem Cell Biol. 2019 Jun;49(1):e77.
24. Guo J, Grow EJ, Mlcochova H, Maher GJ, Lindskog C, Nie X, Guo Y, Takei Y, Yun J, Cai L, Kim R, Carrell DT, Goriely A, Hotaling JM, Cairns BR*. The adult human testis transcriptional cell atlas. Cell Res. 2018 Dec;28(12):1141-1157.
25. Guo J, Grow EJ, Yi C, Mlcochova H, Maher GJ, Lindskog C, Murphy PJ, Wike CL, Carrell DT, Goriely A, Hotaling JM, Cairns BR*. Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development. Cell Stem Cell. 2017 Oct 5;21(4):533-546.e6.