張順，研究員，博士生導師。2018年博士畢業於加州大學聖地亞哥分校，隨後於美國麻省理工學院從事博士後研究工作。2023年4月全職加入必威精装版app西汉姆联 。主要從事血管化微生理病理係統的構建及應用。共發表學術論文14篇，其中以第一作者（含共同）在Advanced Functional Materials，Biomaterials，Advanced Science 等雜誌發表論文9篇。

　　體外生理病理係統及類器官模型的不斷發展為生物工程領域的相關應用提供了具有高度生理相關性的體外研究平台。血管係統是人體不可或缺的重要組成，除了作為運輸氧氣、養分以及代謝廢物的通道，還通過各種方式參與人 體內絕大多數的生理病理過程。很多時候體外微生理係統也需要血管係統的參與 來實現相關的功能，以類器官為例，缺少功能性的血管係統是業界公認的製約類 器官技術進一步發展的難題。

　　研究組聚焦於血管生成的底層機製，構建相應微流控平台深入探索多種生化與力學因素對於血管係統生成及維持的影響，並以此為指導開發相應的技術手段，促進體外血管係統（尤其是具有器官特異性的血管係統）穩定、高效、可靠的形成，並進一步探索具有高度生理相關性的血管化微生理病理模型（包括血管化類器官）的構建並拓展其應用。研究組還致力於開發可靠的多能幹細胞分化方案，構建具有病人特異性的血管化模型，為藥物篩選、相關生理病理過程機製探索、人體胚胎及組織發育等相關研究提供理想的研究平台。

1. Wan Z*, Zhang S*, Zhong AX, Xu L, Coughlin MF, Pavlou G, Shelton SE, Nguyen HT, Hirose S, Kim S, Floryan MA. Transmural Flow Upregulates PD‐L1 Expression in Microvascular Networks. Advanced Science. (2024)
2. Wang L, Xu W, Zhang S, Gundberg GC, Zheng CR, Wan Z, Mustafina K, Caliendo F, Sandt H, Kamm R, Weiss R. Sensing and guiding cell-state transitions by using genetically encoded endoribonuclease-mediated microRNA sensors. Nature Biomedical Engineering. (2024)
3. Zhang S*, Wan Z*, Pavlou G, Zhong AX, Xu L, Kamm RD. Interstitial Flow Promotes the Formation of Functional Microvascular Networks In Vitro through Upregulation of Matrix Metalloproteinase‐2. Advanced Functional Materials. (2022)
4. Hajal C*, Offeddu GS*, Shin Y*, Zhang S, Morozova O, Hickman D, Knutson CG, Kamm RD. Engineered human blood–brain barrier microfluidic model for vascular permeability analyses. Nature Protocols. (2022)
5. Wan Z*, Zhang S*, Zhong AX, Shelton SE, Campisi M, Sundararaman SK, Offeddu GS, Ko E, Ibrahim L, Coughlin MF, Liu T. A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts. Biomaterials. (2021)
6. Zhang S, Wan Z, Kamm RD. Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature. Lab on a Chip. (2021)
7. Zhang S, Skinner D, Joshi P, Criado-Hidalgo E, Yeh YT, Lasheras JC, Caffrey CR, Del Alamo JC. Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment. Journal of the Royal Society Interface. (2019)
8. Zhang S, Guy RD, Lasheras JC, Del Alamo JC. Self-organized mechano-chemical dynamics in amoeboid locomotion of Physarum fragments. Journal of physics D: Applied physics. (2017)
9. Lewis OL, Zhang S*, Guy RD, Del Alamo JC. Coordination of contractility, adhesion and flow in migrating Physarum amoebae. Journal of The Royal Society Interface. (2015)